Tetrahedron letters

Large scale Biginelli reaction via water-based biphasic media: a green chemistry strategy

…, S Pednekar, SN Ganguly, H Dang, W He, A Mandadi

文献索引：Bose, Ajay K.; Manhas, Maghar S.; Pednekar, Suhas; Ganguly, Subhendu N.; Dang, Hoang; He, William; Mandadi, Arun Tetrahedron Letters, 2005 , vol. 46, # 11 p. 1901 - 1903

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被引用次数: 60

摘要

An important stage in process development is kilo scale preparation of the target compound. For this reason, a procedure involving water-based biphasic reaction media has been developed for conducting some exothermic reactions on a large scale. This protocol is illustrated by the energy-efficient and rapid preparation of dihydropyrimidinones by a solvent- free, green chemistry procedure applied to the Biginelli reaction using p-toluenesulfonic ...