6-Substituted decahydroisoquinoline-3-carboxylic acids as potent and selective conformationally constrained NMDA receptor antagonists

PL Ornstein, DD Schoepp, MB Arnold…

文献索引：Journal of Medicinal Chemistry, , vol. 35, # 19 p. 3547 - 3560

被引用次数: 45

摘要

... rings prefer a chair-like conformation, the C-3 acid and C-6 tetrazolylmethyl group are in an equatorial orientation and the stereochemistry of 32a is as shown in Scheme I. With the similarities observed for the chemical shifta and ... 3552 Journal of Medicinal Chemistry, 1992, Vol ...

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