6-Substituted decahydroisoquinoline-3-carboxylic acids as potent and selective conformationally constrained NMDA receptor antagonists

PL Ornstein, DD Schoepp, MB Arnold…

Index: Journal of Medicinal Chemistry, , vol. 35, # 19 p. 3547 - 3560

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Citation Number: 45

Abstract

... rings prefer a chair-like conformation, the C-3 acid and C-6 tetrazolylmethyl group are in an equatorial orientation and the stereochemistry of 32a is as shown in Scheme I. With the similarities observed for the chemical shifta and ... 3552 Journal of Medicinal Chemistry, 1992, Vol ...

Synthesis and murine antineoplastic activity of bis [carbamo...

[Anderson, Wayne K.; McPherson, Howard L.; New, James S.; Rick, Arvela C. Journal of Medicinal Chemistry, 1984 , vol. 27, # 10 p. 1321 - 1325]

Exploiting differences in caspase-2 and-3 S 2 subsites for s...

[Maillard, Michel C.; Brookfield, Frederick A.; Courtney, Stephen M.; Eustache, Florence M.; Gemkow, Mark J.; Handel, Rebecca K.; Johnson, Laura C.; Johnson, Peter D.; Kerry, Mark A.; Krieger, Florian; Meniconi, Mirco; Munoz-Sanjuan, Ignacio; Palfrey, Jordan J.; Park, Hyunsun; Schaertl, Sabine; Taylor, Malcolm G.; Weddell, Derek; Dominguez, Celia Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 19 p. 5833 - 5851]

Tetrahydroisoquinoline based sulfonamide hydroxamates as pot...

[Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 1 p. 47 - 50]