β-Carbonyl substituted glutathione conjugates as inhibitors of O. volvulus GST2

…, AJ van Eldik, PH Teesdale-Spittle, E Liebau…

文献索引：Brophy, Peter M.; Campbell, Alison M.; Van Eldik, Annamaria J.; Teesdale-Spittle, Paul H.; Liebau, Eva; Wang, Meng F. Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 9 p. 979 - 981

全文：HTML全文

被引用次数: 21

摘要

A series of β-carbonyl substituted glutathione conjugates were prepared and evaluated as inhibitors of OvGST2. Their specificity for the parasite derived protein was assessed through comparison with their inhibition of human πGST. Inhibition of OvGST2 has been demonstrated at low micromolar concentrations for these conjugates and selectivity for OvGST2 over human π-GST of greater than 10-fold has been achieved.