Ruthenium-catalyzed rearrangement of aldoximes to primary amides in water

R Garcia-Alvarez, AE Diaz-Alvarez, J Borge…

文献索引：Garcia-Alvarez, Rocio; Diaz-Alvarez, Alba E.; Borge, Javier; Crochet, Pascale; Cadierno, Victorio Organometallics, 2012 , vol. 31, # 17 p. 6482 - 6490

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被引用次数: 29

摘要

The rearrangement of aldoximes to primary amides has been studied using the readily available arene-ruthenium (II) complex [RuCl2 (η6-C6Me6){P (NMe2) 3}](5 mol%) as catalyst. Reactions proceeded cleanly in pure water at 100° C without the assistance of any cocatalyst, affording the desired amides in high yields (70–90%) after short reaction times (1– 7 h). The process was operative with both aromatic, heteroaromatic, α, β-unsaturated, and ...