Detoxification Metabolism of o-Dinitrobenzene by the Yeast Issatchenkia orientalis

…, H Kumagai, Y Shimada, T Kashima…

文献索引：Tamaki, Hisanori; Kumagai, Hidehiko; Shimada, Yoshimi; Kashima, Takanori; Obata, Hiroshi; et al Agricultural and Biological Chemistry, 1991 , vol. 55, # 4 p. 951 - 956

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被引用次数: 5

摘要

Culture medium containing 200 μ m O-dinitrobenzene suppressed cell growth of Issatchenkia orientalis for about 24 hr and after a lag phase, the cells began to increase with concomitant metabolism of O-dinitrobenzene by glutathione conjugation. The resulting glutathione conjugate, S-(2-nitrophenyl) glutathione, was further enzymatically metabolized and released into the growth medium. The final metabolite was identified as S-(2- ...