The Journal of Organic Chemistry

3-Imino-1, 4, 2-dioxazolidines by [1+ 2+ 2] cycloaddition of an isocyanide, 2-methyl-2-nitrosopropane, and a carbonyl compound

D Moderhack, K Stolz

文献索引：Moderhack, Dietrich; Stolz, Karsten Journal of Organic Chemistry, 1986 , vol. 51, # 5 p. 732 - 734

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被引用次数: 6

摘要

F tion and/or migration steps. Complete HD exchange of the vinylic proton in both I11 and V in CD, OD solution (see AA'in Scheme 11) is clearly evident from the NMR spectrum. This type of exchange in aqueous media, over a range of pH values, for ranitidine and related model compounds, has been thoroughly investigated and was found to be of pseudo- firstorder pH-dependent kinetics. It should be noted, however, that even at a pH of ca. 6, ...