New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy

SM Marques, CC Abate, S Chaves, F Marques…

文献索引：Marques, Sergio M.; Abate, Claudia C.; Chaves, Silvia; Marques, Fernanda; Santos, Isabel; Nuti, Elisa; Rossello, Armando; Santos, M. Amelia Journal of Inorganic Biochemistry, 2013 , vol. 127, p. 188 - 202

全文：HTML全文

被引用次数: 5

摘要

Abstract The key role of some matrix metalloproteinases (MMPs) on several pathological processes, including carcinogenesis and tumor growth, makes the development of MMP inhibitors (MMPIs) an attractive approach for cancer therapy. We present herein an integrated approach for the development of a new series of inhibitors of MMP2 and MMP14, two enzymes over-expressed by human ovarian cancer. As a first step, a new series of ...