New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy

SM Marques, CC Abate, S Chaves, F Marques…

Index: Marques, Sergio M.; Abate, Claudia C.; Chaves, Silvia; Marques, Fernanda; Santos, Isabel; Nuti, Elisa; Rossello, Armando; Santos, M. Amelia Journal of Inorganic Biochemistry, 2013 , vol. 127, p. 188 - 202

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Citation Number: 5

Abstract

Abstract The key role of some matrix metalloproteinases (MMPs) on several pathological processes, including carcinogenesis and tumor growth, makes the development of MMP inhibitors (MMPIs) an attractive approach for cancer therapy. We present herein an integrated approach for the development of a new series of inhibitors of MMP2 and MMP14, two enzymes over-expressed by human ovarian cancer. As a first step, a new series of ...