Synthesis

Synthesis of Indolo [3, 2-c] quinoline and Pyrido [3′, 2′: 4, 5][3, 2-c] quinoline Derivatives

A Mouaddib, B Joseph, A Hasnaoui, JY Mérour

文献索引：Mouaddib, Abderrahim; Joseph, Benoit; Hasnaoui, Aissa; Merour, Jean-Yves Synthesis, 2000 , # 4 p. 549 - 556

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被引用次数: 30

摘要

Abstract: Potential antitumoral scaffold indolo [3, 2-c] quinoline 5a was obtained by an intramolecular Heck cyclisation from the corresponding 2-iodophenyl-3-indolecarboxamide 4a. The 7-azaindole analogue 5b was prepared by the same approach. Triflate displacement of compounds 6 according to Suzuki and Stille reactions gave the 6- substituted derivatives 7-10. Key words: indole, 7-azaindole, palladium, cyclisation, ...