Synthesis

Synthesis of Indolo [3, 2-c] quinoline and Pyrido [3′, 2′: 4, 5][3, 2-c] quinoline Derivatives

A Mouaddib, B Joseph, A Hasnaoui, JY Mérour

Index: Mouaddib, Abderrahim; Joseph, Benoit; Hasnaoui, Aissa; Merour, Jean-Yves Synthesis, 2000 , # 4 p. 549 - 556

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Citation Number: 30

Abstract

Abstract: Potential antitumoral scaffold indolo [3, 2-c] quinoline 5a was obtained by an intramolecular Heck cyclisation from the corresponding 2-iodophenyl-3-indolecarboxamide 4a. The 7-azaindole analogue 5b was prepared by the same approach. Triflate displacement of compounds 6 according to Suzuki and Stille reactions gave the 6- substituted derivatives 7-10. Key words: indole, 7-azaindole, palladium, cyclisation, ...

~80%

First synthesis of marine alkaloid (±)-bengacarboline

[Pouilhes, Annie; Langlois, Yves; Chiaroni, Angele Synlett, 2003 , # 10 p. 1488 - 1490]

Design, synthesis, and biological activity of potent and sel...

[Hopkins, Corey R.; Czekaj, Mark; Kaye, Steven S.; Gao, Zhongli; Pribish, James; Pauls, Henry; Liang, Guyan; Sides, Keith; Cramer, Dona; Cairns, Jennifer; Luo, Yongyi; Lim, Heng-Keang; Vaz, Roy; Rebello, Sam; Maignan, Sebastian; Dupuy, Alain; Mathieu, Magali; Levell, Julian Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 11 p. 2734 - 2737]