Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anticancer agents: Design, synthesis and biological evaluation

L Shi, R Hu, Y Wei, Y Liang, Z Yang, S Ke

文献索引：Shi, Liqiao; Hu, Rui; Wei, Yanhong; Liang, Ying; Yang, Ziwen; Ke, Shaoyong European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 549 - 556

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被引用次数: 15

摘要

A series of novel anthranilic diamides derivatives containing aryl-isoxazoline moiety were designed and synthesized as a part of our ongoing search for potential anticancer agents. Their structures were confirmed by 1H NMR, 13C NMR and ESI-MS analyses. The preliminary assays showed that some of the compounds displayed moderate to good antitumor activities against human lung cancer (NCI-H460), hepatocellular liver carcinoma ...