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1-2-(Pyridinyl) piperazine derivatives with antianaphylactic, antibronchospastic and mast cell stabilizing activities

A Catto, G Motta, A Tajana, P Cazzulani…

文献索引:Catto, Alberto; Motta, Gianni; Tajana, Alberto; Cazzulani, Pietro; Nardi, Dante; Leonardi, Amedeo Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 13 - 19

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被引用次数: 10

摘要

The synthesis of the tested compounds followed established procedures. Compounds 2, 6, and 7 were prepared by nucleophilic opening with 1-(2-pyridinyl) piperazine of the three- membered ring of the appropriate N-aroylaziridines, obtained by amidation of the corresponding aroyl chlorides (Scheme I, method A). Most of the N-(substituted phenyl)-w-[4- (2-p yridinyl)-1-piperazinyl] alkanamides (5, 9-1 1, 13-17, 19-24, 31-38, 40-42, 49) were ...

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