As a strategy for G-quadruplex ligand design, high selectivity between dsDNA and G-quadruplexDNA is the crucial step for drug design. 6,7 Additionally, the polymorphism of G-quadruplex structures present in the genomes of organisms may be associated with different biological function; thus the challenge of discriminating between different G-quadruplexes with small molecules is also significant. 3,8 Benzimidazole derivatives attracted our attention ...
