Bisbenzimidazole to benzobisimidazole: from binding B-form duplex DNA to recognizing different modes of telomere G-quadruplex

J Huang, G Li, Z Wu, Z Song, Y Zhou, L Shuai…

Index: Huang, Jing; Li, Guorui; Wu, Zhiguo; Song, Zhibin; Zhou, Yangyang; Shuai, Liang; Weng, Xiaocheng; Zhou, Xiang; Yang, Guangfu Chemical Communications, 2009 , # 8 p. 902 - 904

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Citation Number: 17

Abstract

As a strategy for G-quadruplex ligand design, high selectivity between dsDNA and G-quadruplexDNA is the crucial step for drug design. 6,7 Additionally, the polymorphism of G-quadruplex structures present in the genomes of organisms may be associated with different biological function; thus the challenge of discriminating between different G-quadruplexes with small molecules is also significant. 3,8 Benzimidazole derivatives attracted our attention ...