Tetrahedron letters

Solid-phase synthesis of 2-methoxyaniline derivatives by the traceless silicon linker strategy

S Curtet, M Langlois

文献索引：Curtet, Sophie; Langlois, Michel Tetrahedron Letters, 1999 , vol. 40, # 49 p. 8563 - 8566

全文：HTML全文

被引用次数: 16

摘要

Application of the silicon linkage strategy to the solid-phase synthesis of the rich-electron o- anisidine derivatives is described. The protective t-Boc group was easily removed with B- catechol borane and the isocyanate was successfully prepared with the mild reagent (t-Boc) 2O DMAP. Carbamates, ureas or amides were prepared and released by cleavage with TFA at room temperature. This method can be used to prepare small focused libraries with ...