As a part of our ongoing program to develop efficient and green protocols, 13 we wish to describe herein an in-depth analysis of the effect of various solvents on the transamidation reaction. The findings led us to achieve a mild and effective 1,4-dioxane mediated transamidation approach without the use of any catalyst within short time under microwave (MW) irradiation (Scheme 1). ... Catalyst-free transamidation using 1,4-dioxane. Catalyst-free transamidation using ...