Enhanced cell death imaging using multivalent zinc (II)-bis (dipicolylamine) fluorescent probes

BA Smith, KM Harmatys, S Xiao, EL Cole…

文献索引：Cole, Erin L.; Arunkumar, Easwaran; Xiao, Shuzhang; Smith, Bryan A.; Smith, Bradley D. Organic and Biomolecular Chemistry, 2012 , vol. 10, # 30 p. 5769 - 5773

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被引用次数: 11

摘要

There is a clinical need for imaging technologies that can accurately detect cell death in a multitude of pathological conditions. Zinc (II)-bis (dipicolylamine)(Zn2BDPA) coordination complexes are known to associate with the anionic phosphatidylserine that is exposed on the surface of dead and dying cells, and fluorescent monovalent Zn2BDPA probes are successful cell death imaging agents. This present study compared the membrane ...