Enhanced cell death imaging using multivalent zinc (II)-bis (dipicolylamine) fluorescent probes

BA Smith, KM Harmatys, S Xiao, EL Cole…

Index: Cole, Erin L.; Arunkumar, Easwaran; Xiao, Shuzhang; Smith, Bryan A.; Smith, Bradley D. Organic and Biomolecular Chemistry, 2012 , vol. 10, # 30 p. 5769 - 5773

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Citation Number: 11

Abstract

There is a clinical need for imaging technologies that can accurately detect cell death in a multitude of pathological conditions. Zinc (II)-bis (dipicolylamine)(Zn2BDPA) coordination complexes are known to associate with the anionic phosphatidylserine that is exposed on the surface of dead and dying cells, and fluorescent monovalent Zn2BDPA probes are successful cell death imaging agents. This present study compared the membrane ...