Structure–activity relationships imply different mechanisms of action for ochratoxin A-mediated cytotoxicity and genotoxicity

K Hadjeba-Medjdoub, M Tozlovanu…

文献索引：Hadjeba-Medjdoub, Kheira; Tozlovanu, Mariana; Pfohl-Leszkowicz, Annie; Frenette, Christine; Paugh, Robert J.; Manderville, Richard A. Chemical Research in Toxicology, 2012 , vol. 25, # 1 p. 181 - 190

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被引用次数: 27

摘要

Ochratoxin A (OTA) is a fungal toxin that is classified as a possible human carcinogen based on sufficient evidence for carcinogenicity in animal studies. The toxin is known to promote oxidative DNA damage through production of reactive oxygen species (ROS). The toxin also generates covalent DNA adducts, and it has been difficult to separate the biological effects caused by DNA adduction from that of ROS generation. In the current study, we have ...