Photochemically Catalyzed Reaction of Ochratoxin A with d??and l??cysteine

…, MW Wright, IG Gillman, RA Manderville

文献索引：Brow, Mark E.; Dai, Jian; Park, Gyungse; Wright, Marcus W.; Gillman, Ivan G.; Manderville, Richard A. Photochemistry and Photobiology, 2002 , vol. 76, # 6 p. 649 - 656

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被引用次数: 13

摘要

ABSTRACT The photolysis (> 300 nm) of ochratoxin A (OTA, N-{[(3R)-5-chloro-8-hydroxy-3- methyl-1-oxo-7-isochromanyl] carbonyl}-3-phenyl-l-alanine, 1) in the presence of excess (2 and 12 molar equiv) cysteine (CySH) has been investigated and found to yield sulfur adducts 5 and 6 that are characterized by liquid chromatography–mass spectrometry and 1 H-NMR spectroscopy. The adduct 5 was ascribed to the Michael addition conjugate ...