Indoles and pyridazino [4, 5-b] indoles as nonnucleoside analog inhibitors of HIV-1 reverse transcriptase

…, A Cuartero, A Elorriaga, JJ Martínez-Irujo…

文献索引：Font, M.; Monge, A.; Cuartero, A.; Ellorriaga, A.; Martinez-Irujo, J.J.; et al. European Journal of Medicinal Chemistry, 1995 , vol. 30, # 12 p. 963 - 972

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被引用次数: 43

摘要

The synthesis and the study of the activity of new indol-2-carboxamides and pyridazino [4, 5- b] indoles as inhibitors of HIV-1 reverse transcriptase (RT) are presented. The activity of the compounds synthesized as inhibitors of different types of HIV-1 RT (wild type enzyme and mutant forms P236L, Y 181C and P236L/Y181C) was evaluated. The activity of the most active compounds was investigated in the syncytia reduction in vitro assay, in HIV-1IIIB- ...