Acta Chem. Scand

Chloromethoxysilanes as protecting reagents for sterically hindered alcohols

LL Gundersen, T Benneche, K Undheim

文献索引：Gundersen, Lise-Lotte; Benneche, Tore; Undheim, Kjell Acta Chemica Scandinavica, 1989 , vol. 43, # 7 p. 706 - 709

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被引用次数: 29

摘要

Organosilicon reagents have been widely used for the protection of hydroxy groups in organic synthesis. 1 The stability of the silyloxy function depends largely on the carbon substituents on silicon. The trimethylsilyl derivatives are sensitive to hydrolysis whereas the reri-butyldimethylsilyl (TBDMS) derivatives require stronger hydrolytic conditions for cleavage, and therefore have a wider application potential. 2 TBDMS chloride will convert ...