Acta Chem. Scand

Chloromethoxysilanes as protecting reagents for sterically hindered alcohols

LL Gundersen, T Benneche, K Undheim

Index: Gundersen, Lise-Lotte; Benneche, Tore; Undheim, Kjell Acta Chemica Scandinavica, 1989 , vol. 43, # 7 p. 706 - 709

Full Text: HTML

Citation Number: 29

Abstract

Organosilicon reagents have been widely used for the protection of hydroxy groups in organic synthesis. 1 The stability of the silyloxy function depends largely on the carbon substituents on silicon. The trimethylsilyl derivatives are sensitive to hydrolysis whereas the reri-butyldimethylsilyl (TBDMS) derivatives require stronger hydrolytic conditions for cleavage, and therefore have a wider application potential. 2 TBDMS chloride will convert ...