Chemical Communications

Addition of lithium carbenoids to isocyanates: a direct access to synthetically useful N-substituted 2-haloacetamides

V Pace, L Castoldi, W Holzer

文献索引：Pace, Vittorio; Castoldi, Laura; Holzer, Wolfgang Chemical Communications, 2013 , vol. 49, # 75 p. 8383 - 8385

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被引用次数: 29

摘要

The addition of lithium carbenoids to isocyanates provides a versatile access to N- substituted 2-haloacetamides: the reaction tolerates the presence of variously functionalized substituents on the nitrogen atom, including sterically demanding ones and reactive halogens. No erosion of the enantiopurity was observed in the case of optically active isocyanates. One of the substrates prepared has been employed in Charette's type ...