Abstract The present study describes the synthesis of novel diaryl urea derivatives derived from aryl amine and aryl isocyanates. The synthesized compounds are analogs of sorafenib [4-[4-[[[4-chloro-3-(trifluoromethyl) phenyl] amino] carbonyl] amino] phenoxy]-N- methylpyridine-2-carboxamide] having potential antiproliferative activity.
