Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety

JK Lynch, JC Freeman, AS Judd…

文献索引：Journal of Medicinal Chemistry, , vol. 49, # 22 p. 6569 - 6584

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被引用次数: 41

摘要

... Journal of Medicinal Chemistry. ... Chemistry. The synthesis of 2-carboxychromones 4 was accomplished in three steps by acylation of 2'-hydroxyacetophenones 3 with diethyl oxalate, ring closure by treatment with concentrated ...