Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety

JK Lynch, JC Freeman, AS Judd…

Index: Journal of Medicinal Chemistry, , vol. 49, # 22 p. 6569 - 6584

Full Text: HTML

Citation Number: 41

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. The synthesis of 2-carboxychromones 4 was accomplished in three steps by acylation of 2'-hydroxyacetophenones 3 with diethyl oxalate, ring closure by treatment with concentrated ...

 Related Synthetic Route
2,4-Difluorophenyl acetate Structure

36914-77-9

2,4-Difluorophe...

~%

3,5-Difluoro-2-hydroxyacetophenone Structure

140675-42-9

3,5-Difluoro-2-...

3-Bromophenol Structure

591-20-8

3-Bromophenol

~%

1-(4-Bromo-2-hydroxyphenyl)ethanone Structure

30186-18-6

1-(4-Bromo-2-hy...

1-(4-Chloro-2-methoxyphenyl)ethanone Structure

60207-19-4

1-(4-Chloro-2-m...

~%

1-(4-Chloro-2-hydroxyphenyl)ethanone Structure

6921-66-0

1-(4-Chloro-2-h...

4-Chloro-2,N-dimethoxy-N-methyl-benzamide Structure

205320-02-1

4-Chloro-2,N-di...

~%

1-(4-Chloro-2-hydroxyphenyl)ethanone Structure

6921-66-0

1-(4-Chloro-2-h...

4-Chloro-2-methoxybenzoic acid Structure

57479-70-6

4-Chloro-2-meth...

~%

1-(4-Chloro-2-hydroxyphenyl)ethanone Structure

6921-66-0

1-(4-Chloro-2-h...

4-Chloro-2-methoxybenzoic acid Structure

57479-70-6

4-Chloro-2-meth...

N,O-Dimethylhydroxylamine hydrochloride Structure

6638-79-5

N,O-Dimethylhyd...

~%

4-Chloro-2,N-dimethoxy-N-methyl-benzamide Structure

205320-02-1

4-Chloro-2,N-di...


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