Synthesis and evaluation of acyl protein thioesterase 1 (APT1) inhibitors

…, P Deck, A Giannis, H Waldmann

文献索引：Biel, Markus; Deck, Patrick; Giannis, Athanassios; Waldmann, Herbert Chemistry - A European Journal, 2006 , vol. 12, # 15 p. 4121 - 4143

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被引用次数: 41

摘要

Abstract Lipid-modified proteins play decisive roles in important biological processes such as signal transduction, organisation of the cytoskeleton and vesicular transport. Lipidation of these proteins is essential for correct biological function. Among the modifications with lipids, prenylation and myristoylation are well understood. However, the machinery of palmitoylation is still under investigation. Recently, an enzyme, acyl protein thioesterase 1 ...