Palladium-catalyzed carbonylation. A new synthesis of. alpha.-methylene. gamma.-,. delta.-,. epsilon.-lactams and lactones including bicyclic lactams of pyrrolizidine …
The insertion of carbon monoxide into vinyl halides bearing the secondary amine or alcohol with a catalytic amount of Pd (OA& and PPh, was realized to give five-, six-, and seven- membered lactams and lactones carrying a-methylene groups in fairly good yields. Bicyclic heterocycles, pyrrolizidine and indolizidine derivatives, were also synthesized from pyrrolidine and piperidine derivatives possessing vinyl halide groups in the side chain at ...
