Palladium-catalyzed carbonylation. A new synthesis of. alpha.-methylene. gamma.-,. delta.-,. epsilon.-lactams and lactones including bicyclic lactams of pyrrolizidine …

…, T Urayama, K Yoshiura, K Chiba, Y Ban

Index: Mori, Miwako; Washioka, Yumiko; Urayama, Takao; Yoshiura, Kagari; Chiba, Katsumi; Ban, Yoshio Journal of Organic Chemistry, 1983 , vol. 48, # 22 p. 4058 - 4067

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Citation Number: 83

Abstract

The insertion of carbon monoxide into vinyl halides bearing the secondary amine or alcohol with a catalytic amount of Pd (OA& and PPh, was realized to give five-, six-, and seven- membered lactams and lactones carrying a-methylene groups in fairly good yields. Bicyclic heterocycles, pyrrolizidine and indolizidine derivatives, were also synthesized from pyrrolidine and piperidine derivatives possessing vinyl halide groups in the side chain at ...

 Related Synthetic Route

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