The Journal of organic chemistry

Planar-chiral heterocycles as ligands in metal-catalyzed processes: enantioselective addition of organozinc reagents to aldehydes

PI Dosa, JC Ruble, GC Fu

文献索引：Dosa, Peter I.; Ruble, J. Craig; Fu, Gregory C. Journal of Organic Chemistry, 1997 , vol. 62, # 3 p. 444 - 445

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被引用次数: 206

摘要

As part of a program directed toward the development of new families of chiral nucleophilic catalysts and new classes of chiral ligands, we have begun to explore the chemistry of 2- substituted heterocycles that are π-bound to transition metals (eg, 1). 1 Such complexes are chiral by virtue of the presence of MLn and the differentiation of R from H, and the asymmetric environment around the Lewis-basic heteroatom can readily be “tuned” by ...