Preparation of polyfunctional arylmagnesium, arylzinc, and benzylic zinc reagents by using magnesium in the presence of LiCl

…, BA Haag, A Gavryushin, P Knochel

文献索引：Piller, Fabian M.; Metzger, Albrecht; Schade, Matthias A.; Haag, Benjamin A.; Gavryushin, Andrei; Knochel, Paul Chemistry - A European Journal, 2009 , vol. 15, # 29 p. 7192 - 7202

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被引用次数: 151

摘要

Abstract The presence of LiCl considerably facilitates the insertion of magnesium into various aromatic and heterocyclic bromides. Several functional groups, such as-OBoc,-OTs,- Cl,-F,-CF 3,-OMe,-NMe 2, and-N 2 NR 2, are well tolerated. The presence of a cyano group leads in some cases to competitive reduction of the organic halide to the corresponding ArH compound. The presence of sensitive groups such as methyl or ethyl ester is tolerated ...