Tetrahedron

Convenient approaches to heterocycles via copper-catalysed additions of organic polyhalides to activated olefins

P Martin, E Steiner, J Streith, T Winkler, D Bellš

文献索引：Martin, Pierre; Steiner, Eginhard; Streith, Jacques; Winkler, Tammo; Bellus, Daniel Tetrahedron, 1985 , vol. 41, # 19 p. 4057 - 4078

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被引用次数: 84

摘要

An efficient method for the synthesis of 2, 3-dichloro-5-substituted (Cl, CF3, alkyl) pyridines 29 starting from the 1: 1 adducts of the copper-catalysed addition of chloral or the corresponding 2, 2-dichloroaldehydes to acrylonitrile is presented. Proper choice of experimental conditions allows the preparation of 29 in a one-pot process. Similarly, the CuCl-catalysed reaction of methyl itaconate with several trichloromethyl compounds R- ...