[Mezlocillin: a penicillin from the acylureido series. Synthesis and chemical properties]

…, KG Metzger, HA Offe, W Schröck

文献索引：Koenig, H.-B.; Metzger, K. G.; Offe, H.-A.; Schroeck, W. Arzneimittel Forschung, 1983 , vol. 33, # 1 p. 88 - 90

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被引用次数: 1

摘要

Mezlocillin, 6-[D-2-(2-Oxo-3-mesyl-imidazolidine-1-carboxamido)-2-phenylacetamido]- penicillanic acid, is a new semisynthetic acylureido-penicillin with a broad spectrum of antibacterial activity. The synthesis of mezlocillin from ampicillin and from 6- aminopenicillanic acid and the physicochemical properties are described. Mezlocillin is cleaved by penicillinase to the penicilloate which is degraded further by acids to the ...