Enantiocomplementary Chemoenzymatic Asymmetric Synthesis of (R)??and (S)??Chromanemethanol

…, Y Simeo, BT Ueberbacher, B Mautner…

文献索引：Fuchs, Michael; Simeo, Yolanda; Ueberbacher, Barbara T.; Mautner, Barbara; Netscher, Thomas; Faber, Kurt European Journal of Organic Chemistry, 2009 , # 6 p. 833 - 840

全文：HTML全文

被引用次数: 12

摘要

Abstract A non-lipase-based, enantiocomplementary chemoenzymatic route towards enantiopure (R)-and (S)-chromanemethanol (12), which are the key building blocks for the synthesis of stereoisomerically pure α-tocopherols, has been achieved by the biocatalytic resolution of a racemic 2, 2-disubstituted oxirane using an epoxide hydrolase and a halohydrin dehalogenase, which exhibit opposite enantiopreferences. The introduction of ...