Abstract A non-lipase-based, enantiocomplementary chemoenzymatic route towards enantiopure (R)-and (S)-chromanemethanol (12), which are the key building blocks for the synthesis of stereoisomerically pure α-tocopherols, has been achieved by the biocatalytic resolution of a racemic 2, 2-disubstituted oxirane using an epoxide hydrolase and a halohydrin dehalogenase, which exhibit opposite enantiopreferences. The introduction of ...
