The Journal of organic chemistry

Titration of Nonstabilized Diazoalkane Solutions by Fluorine NMR

VL Rendina, JS Kingsbury

文献索引：Rendina, Victor L.; Kingsbury, Jason S. Journal of Organic Chemistry, 2012 , vol. 77, # 2 p. 1181 - 1185

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被引用次数: 10

摘要

A new protocol for titrating nonstabilized diazoalkane solutions by quantitative 19F NMR is reported. An excess of 2-fluorobenzoic acid dissolved in CDCl3 is treated with the diazoalkane solution at a low temperature, immediately forming the corresponding 2- fluorobenzoate ester upon warming. A significant difference in the 19F chemical shift between the ester and acid is seen, allowing facile and accurate integration to determine ...