Antiobesity, antioxidant and cytotoxicity activities of newly synthesized chalcone derivatives and their metal complexes

MRES Aly, HHAER Fodah, SY Saleh

文献索引：El Sayed Aly, Mohamed Ramadan; Abd El Razek Fodah, Hamadah Hamadah; Saleh, Sherif Yousef European Journal of Medicinal Chemistry, 2014 , vol. 76, p. 517 - 530

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被引用次数: 15

摘要

Abstract Four sets of rationally designed chalcones were prepared for evaluation of their antiobesity, antioxidant and cytotoxicity activities. These sets include nine oleoyl chalcones as mimics of oleoyl estrone, three monohydroxy chalcones (chalcone ligands), Schiff base- derived chalcones and four copper as well as zinc complexes. Oleoyl chalcones 4d, 4e and particularly 6a as an isosteric isomer of oleoyl estrone, were as active as Orlistat on weight ...