Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis

…, T Murase, Y Shigetsura, K Narise, GL Semenza…

文献索引：Hattori, Hisanori; Okuda, Kensuke; Murase, Tetsuji; Shigetsura, Yuki; Narise, Kosuke; Semenza, Gregg L.; Nagasawa, Hideko Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 18 p. 5392 - 5401

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被引用次数: 39

摘要

The tumor microenvironment is characterized by hypoxia, low-nutrient levels, and acidosis. A natural product chemistry-based approach was used to discover small molecules that modulate adaptive responses to a hypoxic microenvironment through the hypoxia-inducible factor (HIF)-1 signaling pathways. Five compounds, such as baccharin (3), beturetol (4), kaempferide (5), isosakuranetin (6), and drupanin (9), that modulate HIF-1-dependent ...