Nickel-mediated regio-and chemoselective carboxylation of alkynes in the presence of carbon dioxide

…, S Nakagawa, T Koizumi, K Hirayama…

文献索引：Saito, Shinichi; Nakagawa, Satomi; Koizumi, Toru; Hirayama, Kyoko; Yamamoto, Yoshinori Journal of Organic Chemistry, 1999 , vol. 64, # 11 p. 3975 - 3978

全文：HTML全文

被引用次数: 101

摘要

Alkynes are carboxylated in a highly regio-and chemoselective manner in the presence of Ni (cod) 2, DBU, and CO2 to give the carboxylated products in good yields. The reaction was carried out under very mild conditions (CO2 1 atm, 0° C) in the presence of a stoichiometric amount of alkynes, conjugated enynes, or diynes. The high selectivity observed in the reaction would be explained in terms of the stability and the reactivity of the intermediates.