Abstract Biphenyl-based phosphine ligands can be prepared on a significantly larger scale than previously possible as a result of the following discoveries and improvements to the original experimental procedure: the finding that CuCl catalyzes the coupling of hindered dialkylchlorophosphines with Grignard reagents; the development of conditions that permit ClPCy 2 to be prepared and utilized in situ; the development of a more reliable large-scale ...
[Wolfe, John P.; Singer, Robert A.; Yang, Bryant H.; Buchwald, Stephen L. Journal of the American Chemical Society, 1999 , vol. 121, # 41 p. 9550 - 9561]
