The Use of Catalytic Amounts of CuCl and Other Improvements in the Benzyne Route to Biphenyl??Based Phosphine Ligands

…, JM Fox, FA Hicks, SL Buchwald

Index: Kaye, Steven; Fox, Joseph M.; Hicks, Frederick A.; Buchwald, Stephen L. Advanced Synthesis and Catalysis, 2001 , vol. 343, # 8 p. 789 - 794

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Citation Number: 97

Abstract

Abstract Biphenyl-based phosphine ligands can be prepared on a significantly larger scale than previously possible as a result of the following discoveries and improvements to the original experimental procedure: the finding that CuCl catalyzes the coupling of hindered dialkylchlorophosphines with Grignard reagents; the development of conditions that permit ClPCy 2 to be prepared and utilized in situ; the development of a more reliable large-scale ...