Nucleotide chemistry. 16. Amidine protecting groups for oligonucleotide synthesis

…, R Kierzek, SL Beaucage, MH Caruthers

文献索引：McBride, Lincoln J.; Kierzek, Ryszard; Beaucage, Serge L.; Caruthers, Marvin H. Journal of the American Chemical Society, 1986 , vol. 108, # 8 p. 2040 - 2048

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被引用次数: 207

摘要

Abstract: Amidines have been investigated for protection of deoxyadenosine, deoxycytidine, 5-methyldeoxycytidine, cytidine, and deoxyguanosine. These amidine-protected nucleosides and their 5'-bis (p-anisylphenyI) methyl derivatives were prepared in high yield (79-100%) by simple one-flask procedures, converted to their respective phosphoramidites [3'-O-((diiso-propylamino) methoxyphosphino)] with bis (diisopropylamino) ...