Nucleosides, Nucleotides and Nucleic Acids

Efficient Syntheses of Clofarabine and Gemcitabine From 2-Deoxyribonolactone

Y Cen, AA Sauve

文献索引：Cen, Yana; Sauve, Anthony A. Nucleosides, Nucleotides and Nucleic Acids, 2010 ,  vol. 29,  # 2  p. 113 - 122

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被引用次数: 5

摘要

The development of a new methodology to achieve electrophilic fluorination of triisopropylsilyl-protected 2-deoxyribonolactone has been employed to synthesize clofarabine and gemcitabine with improved synthetic efficiency versus prior synthetic methods. These studies highlight the versatility of this new methodology to obtain medically relevant 2′-fluoronucleosides.