The relative configuration of the two diastereoisomers of (±) 2-[∢-(2-ethoxyphenoxy) benzyl] morpholine is determined by a synthesis involving regio and stereo specific reactions.(RS, RS) diastereoisomer FCE 20124 was separated into its (+) and (-) enantiomers both by crystallization of the optically active mandelate salt and by a multi-step synthesis from (+)- (2S, 3R)-3-phenylglycidic acid.
