Four sulfur-containing analogues of phenylpropylamine were synthesized and evaluated as substrates for dopamine &hydroxylase (DBH) and monoamine oxidase (MAO). All four phenyl aminoethyl sulfides were shown to be good substrates for DBH whereas only the two analogues not possessing a methyl group a to the terminal amino group were substrates for MAO. All four analogues were tested for acute antihypertensive activity in an animal model ...
