Antihypertensive activities of phenyl aminoethyl sulfides, a class of synthetic substrates for dopamine. beta.-hydroxylase

SR Padgette, HH Herman, JH Han…

Index: Padgette; Herman; Hee Han; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 10 p. 1354 - 1357

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Citation Number: 43

Abstract

Four sulfur-containing analogues of phenylpropylamine were synthesized and evaluated as substrates for dopamine &hydroxylase (DBH) and monoamine oxidase (MAO). All four phenyl aminoethyl sulfides were shown to be good substrates for DBH whereas only the two analogues not possessing a methyl group a to the terminal amino group were substrates for MAO. All four analogues were tested for acute antihypertensive activity in an animal model ...