The synthesis of amines by the homogeneous hydrogenation of secondary and primary amides

…, GR Eastham, DJ Cole-Hamilton

文献索引：Nunez Magro, Angel A.; Eastham, Graham R.; Cole-Hamilton, David J. Chemical Communications, 2007 , # 30 p. 3154 - 3156

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被引用次数: 50

摘要

We now report the selective hydrogenation of amides to primary or secondary amines under relatively mild conditions catalysed by the ruthenium–triphos catalyst (Fig. 2). 6,8 † When N-phenylnonamide was used as substrate, in the absence of ruthenium precatalyst, no conversion was obtained (Table 1, entries 1 and 3). The use of [Ru(acac) 3 ] gave a moderate yield of 61% (Table 1, entry 2) while the combination of [Ru(acac) 3 ] and triphos gave full conversion and high ...