0, O-Diethyl phthalimidophosphonothioate reacts with aniline, isopropylamine, p- nitrophenylhydrazine, SO-dium methoxide, potassium hydroxide, and sodium borohydride by displacement on the carbonyl carbon to produce N-(diethoxyphosphinothioy1) phthalamic acid derivatives, with sodium p-chlorophenate by displacement on phosphorus, and with thiourea by displacement on saturated carbon. The alkaline hydrolysis is first ...
[Lim, Herman D.; Smits, Rogier A.; Bakker, Remko A.; Van Dam, Cindy M. E.; De Esch, Iwan J. P.; Leurs, Rob Journal of Medicinal Chemistry, 2006 , vol. 49, # 23 p. 6650 - 6651]